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Drywall can be toxic to the environment and to humans in some cases. As drywall breaks down in a landfill and comes in contact with other organic chemicals, it can create hydrogen sulfide gas or leach into the groundwater. Additionally, the CDC recommends methods for controlling the inhalation of drywall dust when handled. While the common ingredients of drywall—gypsum, silica, and mica—are naturally occurring, they can cause irritation in some humans.

Whether you need a drywall anchor depends on the specifics of your project, particularly what you're hanging and where. You do not need a drywall anchor if you can screw or nail the object directly into a wooden stud, as the wood provides sufficient support and stability. However, if there are no studs in the location where you plan to hang the item, you should use drywall anchors to ensure it is securely supported. For very lightweight objects, like small pictures, adhesive picture hanging strips can be a suitable alternative to anchors.

Whether a drywall anchor can be reused depends on its material, type, and the method of removal. Plastic anchors, including expansion and self-drilling types, are generally designed for single use as they tend to break or deform upon removal. Metal anchors, such as toggle bolts, are more durable and may be reusable if they are not damaged during extraction. However, with toggle bolts, the toggle piece can fall into the wall cavity when the bolt is removed, making it difficult to retrieve. If an anchor is damaged during removal, for instance by having its head cut off, it cannot be reused regardless of the material.