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Luckily, skunks aren’t challenging to get rid of. You can try to remove them slowly by filling their den entryway loosely with newspaper. Many skunks notice their den is in jeopardy and take off on their own. You can also try making a homemade spray of jalapeno pepper, yellow onion, and cayenne pepper—believe it or not, skunks are sensitive to these smells, so if you spray this around the den or in hard-to-reach places around your property, most skunks will take the hint and leave. 

According to the Internet Center for Wildlife Damage Management, no frightening devices are proven effective for squirrel control. This is likely because the squirrels quickly become habituated to the noises. However, strobe lights show some promise, so motion-activated lighting could be an option worth considering as part of your integrated pest management strategy.

If the nest is on or in your home, you should have an exterminator remove it. However, if the wasp nest is in an area of your yard that you don't frequent, you can leave it alone as long as the wasps don’t bother your household members. Wasps are very active during the summer months, but they will vacate in the fall and not return until the following year. So, if it's safe to do so, you can leave it, but if it poses a threat of being stung because it's in an area that you use frequently, consider having it removed.

You can take multiple approaches to keep animals out of your edible landscape. You can use natural repellents such as mint and cayenne pepper to deter them from your garden. You can also build a fence (or opt for a privet hedge) or keep the most enticing plants in a sectioned-off area. The most efficient method of keeping your four-legged guests at bay is to determine what animal it is and create a customized plan for them.