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Glyphosate and other non-selective herbicides can kill orchard grass, but they will also kill the surrounding plants. Also, not all areas allow the use of glyphosate due to its environmental impact—which the EPA describes as a "potential risk to terrestrial and aquatic plants and birds, and low toxicity to honeybees." Consider mechanical removal to target the plants specifically.

It’s not legal to intentionally damage a neighbor’s tree. Even if the roots of a tree encroach into your yard, if you damage or kill a tree that belongs to your neighbor, you can be held liable for the damage in most cases. Since herbicides can spread through the tree, causing damage to the whole tree and not just the roots that are on your side of the property line, you shouldn’t poison your neighbor’s tree. The other downside to this method is that if the tree dies, it can fall onto your property and cause more damage, so herbicides are best avoided in this circumstance.

If possible, you should prioritize pulling weeds up by hand. However, be sure not to use your bare hands, as many weeds are sharp or otherwise irritating when they come in contact with skin. Always don thick, protective gardening gloves to protect your hands when you pull up weeds.

Weed control applications usually cost around $100 each for a standard-size yard, and most professionals charge between $30 and $60 per hour for manual weed removal. Your total is affected most by the size of the weeded area. Some weed service companies offer weed control treatments, selective herbicide spraying, and manual removal and upkeep as part of a package, costing around $600 annually. You might pay less if you hire the same company for other lawn services, like flower bed upkeep, aeration, overseeding, and pesticide application.