The best way to prevent weeds is to use polymeric sand, which hardens and blocks weed growth when activated with water. If you're using regular sand, you'll need to refill and compact it more often. Keeping the surface clean and free of debris can also help prevent weed seeds from settling in the joints.

Weeds can grow through rubber mulch, but it depends on if you removed all the weeds in your garden beforehand. Weeds already in the soil can grow even when using rubber mulch. However, that doesn’t mean that your garden will be littered with rubber and weeds, but it does mean that the occasional weed might still pop up. Another way you can increase your weed suppression is by using landscape fabric as a second layer. 

Weeds may grow back when pulled out if the root is not completely removed. Invasive weeds can regrow from just a small portion of remaining root, so using a weed-pulling tool can help ensure you remove the entire root. Weeds may grow back faster if roots aren’t fully removed, and incomplete removal could cause them to spread as well.

Clover lawns stand up better against dog and cat urine than traditional turfgrass. If your pets love to hang out on the lawn on a sunny day—or if you find yourself with a lot of visiting neighborhood dogs—you could save yourself from yellow and brown patches by making the switch to a clover lawn.