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The best drain cleaners are biodegradable ones or a mixture of baking soda and vinegar. Strong, caustic chemicals may seem appealing with promises of unclogging your drain quickly, but liquid drain cleaners can cause damage to your pipes over time. Consider making your own drain cleaner with baking soda and vinegar.

Some flushable wipes companies say they are designed to disintegrate within a few hours to a few days after being flushed. These wipes allegedly use materials that are more water-soluble than traditional wipes. However, many experts have raised concerns that even so-called "flushable" wipes do not break down as easily as claimed and can contribute to clogs and blockages in sewer systems.

To prevent plumbing and sewer problems, avoid flushing wipes, even those labeled as flushable. Instead, dispose of them in the trash. This can help prevent costly plumbing issues and reduce the strain on wastewater treatment systems.

A two-way cleanout can help if there’s already a clog, but the best strategy to prevent one is by not rinsing grease, oil, or fat down your drains, not flushing or rinsing coffee grounds or egg shells down your drains, flushing only human waste and toilet paper (so no diapers, period products, bathroom wipes, or paper towels), and using drain guards on all of your drains.

The cost to unclog a drain varies based on the location and severity of the clog. For simple clogs within your home, such as in a sink, toilet, or shower, hiring a plumber typically costs between $110 and $350, with an average of around $200. Snaking a toilet or sink usually costs between $110 and $275, while a bathtub or shower clog costs about $225.

For a more serious clog in the main sewer line, the cost is higher. Clearing a main line clog generally costs between $200 and $600, with an average of about $380. However, prices can range from as low as $100 for snaking a minor clog to over $1,600, particularly if advanced methods like video inspection and hydrojetting are needed for a large or hard-to-reach blockage. Some severe main line clogs can cost upwards of $1,000 to clear depending on factors like the cause of the clog, its distance from an accessible cleanout, and whether the pipe is located beneath an occupied space (e.g., in an apartment building). You may be able to save money on minor clogs by using a drain snake or bladder yourself.