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Most commercial liquid drain cleaners work in 15 to 30 minutes. Consult the label on the bottle for additional instructions or time suggestions to prevent damage to your drainpipes. Alternative solutions such as baking soda, salt, white vinegar, and/or boiling water can take longer since they are less harsh than liquid drain cleaners.

If you’re not using a septic system, problems with your home’s plumbing won’t cause this—it’s a city problem. A large blockage in the municipal sewage lines may cause those lines to back up into your home. This is extremely unpleasant and can be a serious health risk due to bacteria and other contaminants. If this occurs, call a pro (or your city) immediately.

It might be possible to dissolve hair caught in a drain, but it’s usually not a good way to go about clearing the clog. Some sources mention that baking soda and vinegar can do the trick, but this won’t actually dissolve the hair. The hydrochloric acid in drain cleaners can dissolve the hair over time, but it will much more quickly destroy your plumbing pipes and leave you with bigger issues. The best way to remove hair is to do it manually with a drain snake or to have a plumber use an auger to pull clogs out.

Sometimes, the drain is just too clogged—thanks, stubborn hair and soap scum. In this case, you’ll need a more powerful drain cleaner than you can DIY safely at home. But this doesn’t mean you have to choose a traditional drain cleaner. 

You can find biodegradable drain cleaners at your local home improvement store or online for those drains that need a little more oomph. 

While on the hunt for a formidable drain cleaner, the best options are non-chemical clog solutions that combine enzymes and bacteria.