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Squirrels hate not having access to secure shelter or food sources. Your best line of defense is to make your property less attractive by removing access to these things. There are chemical squirrel repellents, but these have mixed success. According to Pennsylvania State University, you can apply products containing the bittering agent denatonium saccharide to a squirrel's favorite fence, tree, or roof spots. However, you need to reapply repellents regularly, which aren’t scientifically proven effective.

It’s very rare to find mice in a bed frame or mattress outside of the most extreme infestation scenarios. That said, your bedroom isn’t off limits for mice if it offers them shelter, food, and warmth. Look for any gaps or openings a mouse could squeeze into, and don’t keep food in your bedroom. 

If you spot two or more cockroaches inside your home, you should hire an exterminator to conduct an inspection and provide eradication treatments. If you see one cockroach and no others, it may have been a stray that wandered inside. Don’t hesitate to call an exterminator as soon as you see more than one cockroach in your home.

Roof rats can carry a variety of pathogens and parasites, including salmonellosis (food contamination), leptospirosis, trichinosis, rat-bite fever, murine typhus, plague, and toxoplasmosis. Diseases can be spread via urine, droppings, or saliva. To prevent transmission, it’s essential to promptly address a roof rat infestation and avoid direct contact with the animals where possible.