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Squirrels hate not having access to secure shelter or food sources. Your best line of defense is to make your property less attractive by removing access to these things. There are chemical squirrel repellents, but these have mixed success. According to Pennsylvania State University, you can apply products containing the bittering agent denatonium saccharide to a squirrel's favorite fence, tree, or roof spots. However, you need to reapply repellents regularly, which aren’t scientifically proven effective.

While you may be hearing squirrels running around your attic at night, these animals are usually more active during the day. If you hear scratching sounds in your attic at night, it’s mostly likely a mouse, raccoon, or bat. Investigate your roof, attic, and other entrances to your home to find signs that indicate the presence of squirrels or other pests.

Luckily, skunks aren’t challenging to get rid of. You can try to remove them slowly by filling their den entryway loosely with newspaper. Many skunks notice their den is in jeopardy and take off on their own. You can also try making a homemade spray of jalapeno pepper, yellow onion, and cayenne pepper—believe it or not, skunks are sensitive to these smells, so if you spray this around the den or in hard-to-reach places around your property, most skunks will take the hint and leave. 

Numerous predators kill hornets, including frogs, birds, lizards, bats, spiders, and hedgehogs. Some larger predators, including rats, skunks, and racoons, will occasionally attack a hornet nest in order to eat the larvae inside. These natural predators typically don’t eat enough hornets to make them an effective form of hornet control.