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No, it's not really possible to completely prevent weed growth. Weeds are incredibly resilient—all they usually need is a tiny bit of dirt to sprout, so their eventual appearance is pretty much inevitable. However, you can definitely keep them at bay by getting rid of weeds as soon as you notice them. The longer you let them sit and grow roots, the more they'll spread.

Sealing pavers helps cut down on weed growth, but it won’t wipe it out entirely. What it does really well is harden the joint sand—especially if you’re using a sealant with polymer additives—so weeds have a much harder time breaking through. It also blocks airborne seeds from settling in the cracks and keeps debris from building up. This results in fewer weeds, easier maintenance, and a cleaner-looking surface. Just remember, sealing is a strong defense—not a one-and-done solution. Stay on top of sweeping, spot-treating, and resealing every few years to keep your weeds in check.

Dandelions, while hard to control and widespread across the country, are not typically categorized as noxious. Yellow starthistle, however, looks very similar to a dandelion and is highly damaging to local plants and invasive across the country.

Glyphosate and other non-selective herbicides can kill orchard grass, but they will also kill the surrounding plants. Also, not all areas allow the use of glyphosate due to its environmental impact—which the EPA describes as a "potential risk to terrestrial and aquatic plants and birds, and low toxicity to honeybees." Consider mechanical removal to target the plants specifically.