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Never use Drano on blocked toilets. You can end up with a ghastly leak because the chemicals eat away at the glue that holds pipes together just as effectively as they do with clogs. Drano is known for being particularly rough on toilets, which is why some plumbers actually dislike the product. 

Disposing of old paint, bleach, oil, and fertilizer should be handled by a company that specializes in this kind of waste. Many private junk removal companies do not dispose of these items. Because these materials are hazardous to the environment and dangerous to handle or dispose of improperly, you should confirm with your local municipality about places to take hazardous materials for safe disposal. 

If you’re not using a septic system, problems with your home’s plumbing won’t cause this—it’s a city problem. A large blockage in the municipal sewage lines may cause those lines to back up into your home. This is extremely unpleasant and can be a serious health risk due to bacteria and other contaminants. If this occurs, call a pro (or your city) immediately.

To break down fat in a septic tank, you will need to hire a professional septic tank cleaner near you to either pump the septic tank or use a shock treatment to clear the clog. It’s important to not pour fat, oil, or grease (memorable with the helpful acronym FOG) down your drains because they can clog the septic system. Instead, you can dispose of them with regular trash, or if your household produces a lot of FOG waste, you may want to install a grease trap for your plumbing.