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An active cleaning agent and a drain snake is the best way to clean a main sewer line. You can purchase a regular or enzyme drain cleaner or make a DIY drain cleaner with baking soda. Use your chosen solution at least once a month or as needed to keep your sewer line clear. 

The best way to unclog a bathtub drain is to pour a pot of boiled water down the drain, being careful not to splash yourself. However, take precautions, as boiling water can damage PVC pipes and joints. Follow up with ½ cup of baking soda and ½ cup of vinegar. Cover the drain with a small sink plunger and let it sit for 15 minutes. Pour boiling water down the drain again and replace the drain stopper.

The cost to unclog a drain varies based on the location and severity of the clog. For simple clogs within your home, such as in a sink, toilet, or shower, hiring a plumber typically costs between $110 and $350, with an average of around $200. Snaking a toilet or sink usually costs between $110 and $275, while a bathtub or shower clog costs about $225.

For a more serious clog in the main sewer line, the cost is higher. Clearing a main line clog generally costs between $200 and $600, with an average of about $380. However, prices can range from as low as $100 for snaking a minor clog to over $1,600, particularly if advanced methods like video inspection and hydrojetting are needed for a large or hard-to-reach blockage. Some severe main line clogs can cost upwards of $1,000 to clear depending on factors like the cause of the clog, its distance from an accessible cleanout, and whether the pipe is located beneath an occupied space (e.g., in an apartment building). You may be able to save money on minor clogs by using a drain snake or bladder yourself.

A liquid drain cleaner can sometimes make a clog worse over time if you use it improperly or too much. The chemicals in drain cleaners can corrode and damage pipes, causing cracks and leaks that may cause further blockages. If the clog is more than the liquid drain cleaner can handle, the cleaner will simply add chemicals to a bigger overall problem.