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You should never use toxic baits or poisons, such as rodenticides designed for mice and rats, to kill or trap possums. Using these toxicants is illegal in many areas and can lead to fines or other penalties. Furthermore, these poisons can cause unnecessary suffering for the animal and pose a significant risk of accidental poisoning to pets or other neighborhood wildlife. Instead of using poisons, it is best to stick with humane methods like live trapping.

Even if you have extreme ophidiophobia (fear of snakes), don’t try to shoot or kill them with a shovel. Besides being pretty cruel, killing snakes in most states is illegal unless your life is at risk and many species are protected. 

Plus, you're putting yourself at greater risk using these techniques if it goes wrong and the now-angry snake is venomous.

One of the best ways to get rid of mice is to prevent them from showing up in the first place with smart tricks—like placing a deterrent around the foundation of your house. Try building a barrier of rocks to make it harder for such rodents to get cozy in the small corners and crawl spaces that might give them access to the interior.

The most effective natural roach repellent is Borax with its key ingredient of boric acid and diatomaceous earth. But some homeowners may not feel like these are “natural” enough, especially since you can’t use Borax around curious pets or toddlers.

On the other hand, studies have shown that oregano oil mixtures have some of the best repellent effects, and other research indicates that catnip oil, peppermint oil, and citrus oils have notable effects on keeping roaches away. Rosemary oil has been shown to be the most effective natural oil for killing cockroaches outright.