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No, it's not really possible to completely prevent weed growth. Weeds are incredibly resilient—all they usually need is a tiny bit of dirt to sprout, so their eventual appearance is pretty much inevitable. However, you can definitely keep them at bay by getting rid of weeds as soon as you notice them. The longer you let them sit and grow roots, the more they'll spread.

Weeds can grow through rubber mulch, but it depends on if you removed all the weeds in your garden beforehand. Weeds already in the soil can grow even when using rubber mulch. However, that doesn’t mean that your garden will be littered with rubber and weeds, but it does mean that the occasional weed might still pop up. Another way you can increase your weed suppression is by using landscape fabric as a second layer. 

A spot herbicide for weed control is effective at killing crabgrass and not grass, but it depends on the type of herbicide. Always check the label to ensure that your herbicide is safe for grass but tough on crabgrass. Overall, spot treatment is ideal because it puts fewer herbicides into the soil, which can damage the soil. If you’re wanting a natural remedy to crabgrass that also won’t harm surrounding grass, you can also hand-remove crabgrass or even pour boiling water or 5% vinegar over crabgrass as a spot treatment.

Poison oak is similar to poison ivy in that it's in the same family of plants. Poison oak is identifiable by its rounded-off leaves and hairy leaf texture. Tree-climbing varieties live primarily in western states while low-growing poison oak bushes occupy the eastern states. Treat poison oak like poison ivy to get rid of it permanently.