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A two-way cleanout can help if there’s already a clog, but the best strategy to prevent one is by not rinsing grease, oil, or fat down your drains, not flushing or rinsing coffee grounds or egg shells down your drains, flushing only human waste and toilet paper (so no diapers, period products, bathroom wipes, or paper towels), and using drain guards on all of your drains.

It is generally safe to stay in a house that smells like sewage for a short time, but you should get the problem fixed as soon as possible. While the level of sewer gas is usually low enough to only cause minor symptoms, prolonged inhalation can lead to headaches, nausea, or respiratory irritation. High levels of gas exposure can be more dangerous, and high concentrations of methane—a component of sewer gas—can pose an explosion risk in enclosed spaces. If you smell sewer gas in your home, ventilate the area and call a professional to locate, assess, and fix the problem, as it will not go away on its own.

A septic system can fail for various reasons, and most commonly, excessive water use or sudden surges in wastewater can overwhelm the system's capacity. Neglecting regular maintenance, like tank pumping and inspections, can also lead to clogs, leaks, and eventual breakdowns. Other issues that lead to failure include age-related wear and tear, root infiltration, improper disposal of non-biodegradable materials or chemicals into the system, unsuitable soil conditions, physical damage, and even environmental factors like flooding or soil erosion.

A septic smell may be harmful because sewer gas is dangerous depending on the exposure amount and length of time. Sewer gas is made up of multiple gases, including hydrogen sulfide, methane, ammonia, and carbon dioxide. Some of these gases, like hydrogen sulfide and ammonia, are toxic to humans and can be fatal in high concentrations or long exposures.