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Bleach and freezing are your best bets here. The soft exoskeleton of spiders and spider eggs is no match to household bleach. Create a mixture that’s half water and half bleach and spray it directly onto the egg sac, and the spider eggs will be killed in less than five minutes. Freezing the egg sac or drowning it in cold water is another option.

Maintaining a clean environment can deter spiders to a certain extent by removing clutter and reducing the number of insects they prey on. Spiders tend to favor secluded spots to spin their webs and hunt for prey, and regular cleaning practices such as dusting, vacuuming, and decluttering can disrupt these ideal conditions. Despite these preventive measures, some spider species are highly adaptable and may still infiltrate your home despite your best efforts to maintain a tidy living space.

You can easily find sprays that claim they are safe for pets and kids. However, we’d rather not use them in our own homes if we’re worried about pet safety: They still include pesticides and other chemicals, and are best avoided in any food prep areas like the kitchen, or any spots where children and pets may place. That’s why sprays didn’t end up in our suggestions for the safest options.

For a non-chemical bed bug treatment, you can try spraying your mattress with a mixture of essential oils, rubbing alcohol, and water. Pesticide sprays are available, but using them can pose potential health risks to humans and pets—especially if they are not applied correctly. If non-chemicals do not eradicate your bed bug infestation, you should consult a pest control specialist to determine the best course of action.