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It might be possible to dissolve hair caught in a drain, but it’s usually not a good way to go about clearing the clog. Some sources mention that baking soda and vinegar can do the trick, but this won’t actually dissolve the hair. The hydrochloric acid in drain cleaners can dissolve the hair over time, but it will much more quickly destroy your plumbing pipes and leave you with bigger issues. The best way to remove hair is to do it manually with a drain snake or to have a plumber use an auger to pull clogs out.

Your sewer line can get grimy quickly. To prevent sludge buildup in your sewer line, pour a mixture of 1/3 cup of vinegar and 1/3 cup of baking soda down each drain in your home once a month. After about 30 minutes, flush the drain with hot water.

Some plumbers recommend 3/4 cup of bleach instead to clean any germs and bacteria that may build up in your sewer line. But this won’t break down any active clogs, and it cannot be combined with vinegar, as the mixture will create a toxic, hazardous gas.

In most cases, drain cleaners will not clear a clogged sewer line, and they’re likely to damage your plumbing. Sewer lines are several inches wide, meaning any material that clogs it will need to be large. Drain cleaner can work on small clogs, but it usually won’t clear a larger one in a sewer main. Drain cleaners can also easily damage and corrode your plumbing with prolonged contact, and a clog will keep the cleaner in contact with the pipes for an extended period. Hire a professional sewer cleaner instead for a safe fix.

Simple blockages can be cleared using household plungers or manual snakes, provided no severe plumbing issues exist.