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This varies based on the circumstance. Chemical-based pest control baits and poisons are usually the most potent, but they are unsafe to use around children and pets, so they won’t be a fit for every household.

Safer alternatives, such as boric acid and food-grade diatomaceous earth, can work as well, though they should still stay out of reach. Aside from that, the best thing any DIY-er can do is make their place uninviting by sealing off entry points, eliminating clutter, and maintaining a clean home.

There are many steps you can take to keep mice out of your home. The most preventative include removing all available food sources, keeping your home clean, and sealing up entry points to your home. You can also try using live traps or even getting a cat. If none of these measures work, enlist the help of a pest control company.

Raccoons should be removed in most cases, especially when they’ve made their way indoors. Even if they seem harmless, raccoons are wild animals that can damage your property and potentially harm you, your family, and your pets. As soon as you notice signs of raccoons on your property, address the situation by securing your garbage and consulting a pro.

Squirrels hate not having access to secure shelter or food sources. Your best line of defense is to make your property less attractive by removing access to these things. There are chemical squirrel repellents, but these have mixed success. According to Pennsylvania State University, you can apply products containing the bittering agent denatonium saccharide to a squirrel's favorite fence, tree, or roof spots. However, you need to reapply repellents regularly, which aren’t scientifically proven effective.