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This varies based on the circumstance. Chemical-based pest control baits and poisons are usually the most potent, but they are unsafe to use around children and pets, so they won’t be a fit for every household.

Safer alternatives, such as boric acid and food-grade diatomaceous earth, can work as well, though they should still stay out of reach. Aside from that, the best thing any DIY-er can do is make their place uninviting by sealing off entry points, eliminating clutter, and maintaining a clean home.

Squirrels rely heavily on their sense of smell and are deterred by a variety of scents. Some of the most effective smells for repelling them include peppermint oil, coffee grounds, white vinegar, garlic, cinnamon, rosemary, and predator urine. They also have a strong aversion to capsaicin, the compound that makes chili peppers hot, making capsaicin-based sprays an effective repellent for areas like gardens or bird feeders. For a DIY solution, you can create a spray from garlic and vinegar and apply it daily. Additionally, squirrels dislike strong, fresh scents, so placing items like strong-smelling soaps or dryer sheets in areas they frequent can also help keep them away.

It’s very rare to find mice in a bed frame or mattress outside of the most extreme infestation scenarios. That said, your bedroom isn’t off limits for mice if it offers them shelter, food, and warmth. Look for any gaps or openings a mouse could squeeze into, and don’t keep food in your bedroom. 

As a general rule, if you hear an animal in your attic, don’t assume it will stay there. Animals are drawn to warmth and food sources, which could lead them to other parts of your house. In particular, it’s likely that small pests such as rats and mice that only need tiny gaps to squeeze through will end up in your walls and ductwork. Larger animals like raccoons may be limited to an enclosed attic.