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There is conflicting advice on whether to leave a baking soda and vinegar mixture in a drain overnight. Some sources suggest it can be effective for tough clogs, recommending that you flush the drain with warm water in the morning as part of a monthly cleaning routine. However, other experts advise against leaving the mixture in for extended periods, as its caustic nature could corrode drainpipes if used too often or left in for too long.

It is generally safe to stay in a house that smells like sewage for a short time, but you should get the problem fixed as soon as possible. While the level of sewer gas is usually low enough to only cause minor symptoms, prolonged inhalation can lead to headaches, nausea, or respiratory irritation. High levels of gas exposure can be more dangerous, and high concentrations of methane—a component of sewer gas—can pose an explosion risk in enclosed spaces. If you smell sewer gas in your home, ventilate the area and call a professional to locate, assess, and fix the problem, as it will not go away on its own.

If you leave liquid drain cleaner for too long, it will start breaking down your drainpipes. The chemicals in these cleaners can cause cracks, corrosion, and leaks in your pipes. They can also damage plumbing fixtures and even cause environmental damage if left too long without rinsing away.

There are a few things that can happen to your sewer system if you don’t fix it. These include rainwater entering it and causing rust and corrosion, dirt and debris leading to blockages, small animals getting stuck inside and clogging your sewer line or entering your home, and shortening the sewer system’s life span. 

Without a cap, nothing prevents toxic and non-toxic gasses like methane and hydrogen sulfide from slowly escaping your sewer system and entering your home and the surrounding atmosphere, resulting in a foul sewer odor throughout your house.