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No, it’s best not to leave baking soda and vinegar in the drain overnight. While using baking soda and vinegar can be helpful to clear out hair and debris in your bathtub drain, this mixture might start to corrode your drainpipes due to its caustic nature if left in the drain too long or used too often. 

In most cases, drain cleaners will not clear a clogged sewer line, and they’re likely to damage your plumbing. Sewer lines are several inches wide, meaning any material that clogs it will need to be large. Drain cleaner can work on small clogs, but it usually won’t clear a larger one in a sewer main. Drain cleaners can also easily damage and corrode your plumbing with prolonged contact, and a clog will keep the cleaner in contact with the pipes for an extended period. Hire a professional sewer cleaner instead for a safe fix.

It is generally safe to stay in a house with sewer gas for a short time, even though short-term exposure is unpleasant. However, prolonged inhalation can cause headaches, nausea, or respiratory irritation. High levels of methane—which is in sewer gas—can pose an explosion risk in enclosed spaces. Ventilate the area and call a pro if you smell sewer gas or experience related health symptoms.

If methods like hot water or a plunger don’t work on your clogged drain, you can snake your drain to dislodge the plug. This can be a messy process, taking some physical effort and additional time over the other drain-clearing options. You can purchase a drain snake at a hardware store and choose from handheld options or those attached to a drill. Just work slowly, and be ready to call a plumber if you’re unable to reach the clog from your drain or P-trap.