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A 50-pound mirror can be hung on drywall, but only if it has the support of strong hardware. Ideally, you can find the studs behind the drywall and attach the mirror to them; this will give your mirror better stability. Otherwise, confirm that you are using anchors appropriate to the weight of the mirrors. Another technique is to use French cleats—two pieces of wood that fit together, with one piece attached to the wall and the other to the mirror. This allows the weight to be distributed over a wider area.

In framing, studs are placed at 16-inch intervals to coincide with the typical spacing of wall materials such as drywall or plywood. This spacing is called "on-center" and is necessary for maintaining structural stability and efficient use of materials. The 16-inch spacing also helps to distribute the weight evenly across the building's structure. For those looking to cut material costs and improve energy efficiency, 24-inch stud spacing can be employed through a method called "advanced framing". This requires careful planning and adherence to local building codes to ensure structural integrity.

For maximum stability, install grab bars on wall studs, as this will adequately support the weight. However, if you don't have access to studs, you can get by with wall anchors. If opting for the latter, choose specialty hollow wall anchors. 

Whether you need a drywall anchor depends on the specifics of your project, particularly what you're hanging and where. You do not need a drywall anchor if you can screw or nail the object directly into a wooden stud, as the wood provides sufficient support and stability. However, if there are no studs in the location where you plan to hang the item, you should use drywall anchors to ensure it is securely supported. For very lightweight objects, like small pictures, adhesive picture hanging strips can be a suitable alternative to anchors.