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It’s debatable, but most will say either termites or bed bugs are the hardest to remove. When dealing with termites, you must find the central nest (as opposed to satellite nests) and exterminate the queen and all potential queens, which often takes the work of a specialist. Bed bugs, meanwhile, are incredibly hardy, good at hiding, and resistant to pesticides, so it takes very careful, very thorough work to get rid of them permanently. 

Boric acid is among the harsher chemicals you can use in your home, and it poses risks whether ingested, inhaled, or touched. Kids and pets alike tend to put their hands and mouths on anything within reach, so it’s always a good idea to store boric acid in a spot they can’t get to and use it only when they’re not around for an extended period. When you use it, ensure they’re out of the house and fully clean up any trace of boric acid when you’re done because even a small amount can cause problems. 

While possums don’t typically carry rabies, they can have lice, fleas, ticks, and mites. According to the University of California’s Pest Management Program, possums can also carry diseases like leptospirosis, tuberculosis, toxoplasmosis, coccidiosis, and fevers. Possums are also the carriers of a parasite that can pass to horses and cats called Equine Protozoal Myeloencephalitis (EPM).

Gophers are ubiquitous in certain areas, and the only way to completely get rid of them is to put down gopher wire two feet below the surface of your soil and vertically along the edges of your yard. Unfortunately, this may not be a practical solution unless you’re completely redoing your yard or installing an aboveground garden. Alternatively, you may consider putting underground rock barriers around the edge of your yard to discourage gopher visits. However, you’ll still likely get some pests because they can dig as deep as 6 feet below the surface.