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Squirrels hate not having access to secure shelter or food sources. Your best line of defense is to make your property less attractive by removing access to these things. There are chemical squirrel repellents, but these have mixed success. According to Pennsylvania State University, you can apply products containing the bittering agent denatonium saccharide to a squirrel's favorite fence, tree, or roof spots. However, you need to reapply repellents regularly, which aren’t scientifically proven effective.

Once the animals and their young are out of the house, remove the nest and locate any entry points. Some may be difficult to find because some animals can fit through very small holes. Once you’ve located as many entry points as possible, use materials such as metal or masonry to block off the entry. Ideally, you should choose materials that most animals cannot chew through. Create a one-way door or flap to allow animals to leave but not return. Additional methods include using repellants designed to make an area unappealing to the types of animals that find your home so inviting. 

Spiders have lots of scent-sensitive hairs on their legs. Scented oils they aren’t fans of can act as a natural spider repellent to help keep their populations at bay when you rub them around your home’s entry points. Studies suggest mint and chestnut oils are two scents that spiders hate.

Getting roaches to completely go away will take a lot of effort, and they hardly ever go away on their own. You will likely need a combination of home treatments, like roach sprays and traps, and regular visits from an exterminator, to control an infestation. It can take awhile for these treatments to start working, and you’ll need to stay on top of replacing old traps and having additional extermination services, plus keeping your home clean and decluttered, to deter roaches.