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Pulling weeds once per month is typically often enough to keep most weeds at bay. But in general, it's best to pull weeds as soon as you spot them to prevent deep root growth and slow their spread. To make it easier, plan your weed pulling after rain or after the sprinklers run so the soil will be nice and wet and the weeds will be easier to pull. If you notice moss accompanying weeds, make a plan to remove the moss immediately to prevent damage.

Buffalo grass is not a dense grass, so weeds can grow between the buffalo grass plants. However, as long as you don’t overwater your lawn, weeds have a hard time growing. If you do notice weeds, you can use granular herbicides that are safe for buffalo grass in early and late summer.

Herbicide application, manual removal, and landscape fabric are common approaches.

No, it's not really possible to completely prevent weed growth. Weeds are incredibly resilient—all they usually need is a tiny bit of dirt to sprout, so their eventual appearance is pretty much inevitable. However, you can definitely keep them at bay by getting rid of weeds as soon as you notice them. The longer you let them sit and grow roots, the more they'll spread.