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There is conflicting advice on whether to leave a baking soda and vinegar mixture in a drain overnight. Some sources suggest it can be effective for tough clogs, recommending that you flush the drain with warm water in the morning as part of a monthly cleaning routine. However, other experts advise against leaving the mixture in for extended periods, as its caustic nature could corrode drainpipes if used too often or left in for too long.

You should hire a sewer service professional to unclog a main sewer line with tree roots. Tree roots can grow into the main sewer line, and this problem requires a specialized hydro jet, or rooter, that is powerful enough to clear the roots. The tree can also damage the main sewer line, and a professional will need to make repairs or replace the damaged sections. Sewer line replacement costs about $60 to $250 per linear foot.

If methods like hot water or a plunger don’t work on your clogged drain, you can snake your drain to dislodge the plug. This can be a messy process, taking some physical effort and additional time over the other drain-clearing options. You can purchase a drain snake at a hardware store and choose from handheld options or those attached to a drill. Just work slowly, and be ready to call a plumber if you’re unable to reach the clog from your drain or P-trap.

Your sewer line can get grimy quickly. To prevent sludge buildup in your sewer line, pour a mixture of 1/3 cup of vinegar and 1/3 cup of baking soda down each drain in your home once a month. After about 30 minutes, flush the drain with hot water.

Some plumbers recommend 3/4 cup of bleach instead to clean any germs and bacteria that may build up in your sewer line. But this won’t break down any active clogs, and it cannot be combined with vinegar, as the mixture will create a toxic, hazardous gas.