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You should never use toxic baits or poisons, such as rodenticides designed for mice and rats, to kill or trap possums. Using these toxicants is illegal in many areas and can lead to fines or other penalties. Furthermore, these poisons can cause unnecessary suffering for the animal and pose a significant risk of accidental poisoning to pets or other neighborhood wildlife. Instead of using poisons, it is best to stick with humane methods like live trapping.

There's anecdotal evidence that apple cider vinegar does help to repel mice. But the best way to repel mice is to keep your home scrupulously clean and seal up any obvious entry points. If you already have a mouse infestation, apple cider vinegar won’t get rid of the critters. It’s usually worth the cost of professional pest control to make sure a serious mouse problem is eradicated completely.

Luckily, skunks aren’t challenging to get rid of. You can try to remove them slowly by filling their den entryway loosely with newspaper. Many skunks notice their den is in jeopardy and take off on their own. You can also try making a homemade spray of jalapeno pepper, yellow onion, and cayenne pepper—believe it or not, skunks are sensitive to these smells, so if you spray this around the den or in hard-to-reach places around your property, most skunks will take the hint and leave. 

Groundhogs are non-aggressive animals that are afraid of humans. They forage for vegetation in yards and gardens, so they can often be seen as a nuisance if you spot one on your property. That said, if you happen to get bitten or scratched by a fearful groundhog, be sure to get checked by a doctor, as they could carry infections or diseases like rabies, Lyme, or the rare tularemia.