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Glyphosate and other non-selective herbicides can kill orchard grass, but they will also kill the surrounding plants. Also, not all areas allow the use of glyphosate due to its environmental impact—which the EPA describes as a "potential risk to terrestrial and aquatic plants and birds, and low toxicity to honeybees." Consider mechanical removal to target the plants specifically.

Pulling weeds can spread weed seeds and disturb the soil, leading to seed germination. Pulling weeds can also trigger growth in weeds that reproduce through their root systems—disturbing the roots without fully removing them may cause more weeds to grow from the roots.

The fastest ways to kill weeds and unwanted grass include burning them, pouring boiling water on them, or pulling them out by hand, as these methods work almost instantaneously. For a quick-acting solution that works within a few hours, you can use a commercial-grade herbicide like glyphosate or a DIY vinegar, salt, and dish soap mixture. While effective, be aware that commercial herbicides introduce chemicals into your lawn. The slowest method for killing weeds is to starve them of sunlight and nutrients using mulch or fabric covers.

Vinegar is known to be a contact herbicide, which means it kills the foliage it comes in contact with. Because of the high acetic acid concentration, horticultural vinegar kills weeds and grass more effectively. However, keep in mind that high amounts and multiple applications can affect the soil by lowering the pH levels.