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While not common, bird’s nests can cause problems to your property in some cases. 

• Block vents for your dryer, stove, and fans, creating a fire hazard

• Clog gutters and drains, leading to roof and siding damage

• Damage solar panels

• Wiring issues if the nest is on or near a light fixture

If you are not at high risk of contracting disease and take proper safety precautions, it’s considered generally safe to clean mouse droppings on your own. Before handling any droppings, make sure to put on protective equipment such as plastic gloves and a face mask. Individuals who are immunocompromised, have medical conditions, and children should especially avoid exposure to mouse droppings. 

There is no exact science here, due to the nature of nests and how mice raise their young, but a good place to start is to inspect the droppings. A single mouse poops a lot, leaving around 50 droppings in a single day, likely near a primary food source. If you find only sporadic droppings, you likely have a small infestation. If you spot large mounds of droppings, you are dealing with a big problem.

Finding mouse droppings without seeing any mice is a common sign of an infestation because mice are nocturnal and skilled at hiding from humans. Droppings are often the first and most visible evidence of their presence. The location, quantity, and freshness of the droppings can help you determine where the mice are most active and how severe the infestation might be. Since mice are active at night and often travel through hidden pathways like inside walls, you may not see them directly. It's important to look for other signs of an infestation, such as gnaw marks, scratching sounds, or greasy trails along walls. If you find droppings, consider setting traps or contacting a professional exterminator to address the issue.