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Ductwork should be wrapped in insulation in certain locations. This includes unconditioned interior parts of the home, such as attics, crawl spaces, basement ceilings, and between floors. Duct joints should also be insulated since they're more likely to leak air than other parts of your system. Building codes in some areas also require ductwork to be insulated.

Mineral wool wraps are the most affordable and effective insulation for crawl space ducts. They are easy to cut, last for a long time, and healthier for humans. Meanwhile, fiberglass wraps are cheaper but more hazardous and difficult to handle. If you do choose to use a fiberglass wrap, make sure you are wearing long sleeves and wear proper protective gear.

The primary downside of radiant barriers is their limited effectiveness in cold climates. They are designed to reflect radiant heat, making them less beneficial in cooler conditions where heat retention is more important. 

Radiant barriers require proper installation to maximize effectiveness. Incorrect placement can lead to minimal benefits. They also do not provide insulation, meaning they should be used in conjunction with traditional insulation for optimal energy efficiency. 

The best type of attic insulation depends on where you live, your budget, and what stage of construction the attic is in. For example, if you're building a house, then structural insulated panels are a worthy investment since they're easy to install during construction and they're the most energy-efficient type of insulation.  

Additionally, if you live in a very warm climate, then you can potentially save quite a bit of money by opting for reflective insulation, which is more affordable than comprehensive insulation but doesn't work well for cool climates. Blown-in, loose-fill, and spray foam insulation are all great options for attics in moderate climates.