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Yes, vinegar can be an effective way to kill individual dandelion plants to help in the hand-removal process. However, vinegar can also kill turfgrass, so use a targeted spray.

Yes, Johnsongrass is a hard weed to kill. It has the ability to grow fast and spread even quicker, so it requires a detailed plan and thorough application to eliminate it. The best plan of action is to kill Johnsongrass while the weed is establishing itself by hiring a lawn care professional or following the steps above. 

No, definitely not. Pulling weeds by hand is the single most effective way to remove them because you're eliminating the entire plant—roots and all—so it won’t have a chance to grow or spread. Setting time aside a few times per week to pull weeds can keep them at bay. If the number of weeds gets overwhelming, then you can resort to other methods.

Typically seasonally, but tailored schedules depend on local conditions and plant types.