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A spot herbicide for weed control is effective at killing crabgrass and not grass, but it depends on the type of herbicide. Always check the label to ensure that your herbicide is safe for grass but tough on crabgrass. Overall, spot treatment is ideal because it puts fewer herbicides into the soil, which can damage the soil. If you’re wanting a natural remedy to crabgrass that also won’t harm surrounding grass, you can also hand-remove crabgrass or even pour boiling water or 5% vinegar over crabgrass as a spot treatment.

The most effective way to eliminate quack grass without killing the grass nearby is to overseed the area, keep the seed wet until it grows, mow often, and regularly fertilize the area to promote healthy grass that can choke out the invasive weed.

Glyphosate and other non-selective herbicides can kill orchard grass, but they will also kill the surrounding plants. Also, not all areas allow the use of glyphosate due to its environmental impact—which the EPA describes as a "potential risk to terrestrial and aquatic plants and birds, and low toxicity to honeybees." Consider mechanical removal to target the plants specifically.

All herbicides come with risks, but you can control and mitigate risks by discussing your options with your weed service company before application. Some companies use milder or sustainable herbicides more times per season to control weeds rather than one to two herbicide sprayings annually. You can also ask your professional about pet-friendly and kid-friendly services. In most cases, though, you can wait a few days after the application for the herbicides to soak into the ground, at that point they shouldn’t pose a risk to you or your family.