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Glyphosate and other non-selective herbicides can kill orchard grass, but they will also kill the surrounding plants. Also, not all areas allow the use of glyphosate due to its environmental impact—which the EPA describes as a "potential risk to terrestrial and aquatic plants and birds, and low toxicity to honeybees." Consider mechanical removal to target the plants specifically.

A spot herbicide for weed control is effective at killing crabgrass and not grass, but it depends on the type of herbicide. Always check the label to ensure that your herbicide is safe for grass but tough on crabgrass. Overall, spot treatment is ideal because it puts fewer herbicides into the soil, which can damage the soil. If you’re wanting a natural remedy to crabgrass that also won’t harm surrounding grass, you can also hand-remove crabgrass or even pour boiling water or 5% vinegar over crabgrass as a spot treatment.

The safest method to avoid killing your turf grass is hand pulling Johnsongrass. You can also apply vinegar for a safer herbicide, but it will still burn your lawn if it gets on it.

Pulling weeds once per month is typically often enough to keep most weeds at bay. But in general, it's best to pull weeds as soon as you spot them to prevent deep root growth and slow their spread. To make it easier, plan your weed pulling after rain or after the sprinklers run so the soil will be nice and wet and the weeds will be easier to pull. If you notice moss accompanying weeds, make a plan to remove the moss immediately to prevent damage.