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Once you’ve poured the baking soda and vinegar into a drain, you should wait about 10 minutes for the mixture to break down the clog. If you try the baking soda and vinegar method and it doesn't work, you can do it again or try the baking soda and salt trick.

To unclog the drain pipe, remove the machine's drain hose from the pipe or sink drain, being careful to contain any water in it. Next, use a plunger for sink drains or a plumbing snake for a wall drain. Test the repair by pouring a small amount of water into the pipe before trying it with a laundry load.

Yes, chemical drain cleaners contain sulfuric acid and hydrochloric acid, both of which are not only dangerous to your health but also extremely caustic. Drain cleaners will corrode your pipes and could lead to destroyed drain lines, especially if the chemicals interact with the piping for long periods. Unfortunately, this extended interaction is likely if you’re dealing with a clog, as the drain cleaner will have just as much trouble as water does moving through your plumbing system.

You should hire a sewer service professional to unclog a main sewer line with tree roots. Tree roots can grow into the main sewer line, and this problem requires a specialized hydro jet, or rooter, that is powerful enough to clear the roots. The tree can also damage the main sewer line, and a professional will need to make repairs or replace the damaged sections. Sewer line replacement costs about $60 to $250 per linear foot.