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Yes, but you should only put tile directly on drywall in smaller areas that don’t experience excess moisture. For example, a small kitchen tile backsplash could work, but installing tile directly on the drywall in a bathroom or other chronically damp area is not a good idea. Either way, a cement backer board is a far more reliable solution, as drywall is susceptible to moisture and can warp or cause your tiles to crack.

There are no unbreakable rules of design, but experts recommend against using large tiles in areas with poor subflooring where they’re more prone to cracking, in areas where the floor isn’t entirely level, over raised areas or dips, and in bathrooms where budget is the primary concern. The size of your bathroom shouldn’t be a reason not to use large tiles; in fact, larger tiles, also known as slab tiles, can be a modern and sleek choice for bathroom floors and walls.

You can let the tile sit without grout. Don’t panic if there’s a delay between installing the tiles and grouting. A substantial stoppage isn't a problem, provided you keep the tile surface clear of dust and debris. Also, avoid walking over less stable ungrouted floor tiles as they are more prone to premature cracking and shifting. 

The rule tells you how to cut tile to install it in a corner. The 3/4/5 rule recommends that you should have 3 feet across on one straight line, four feet on the other perpendicular line, and 5 feet of length from the end of one of the lines to the other. You’re making a right triangle with the tile, and the hypotenuse (the line across from where the 3-foot lie and 4-foot line meet) should be 5 feet long.