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There is conflicting advice on whether to leave a baking soda and vinegar mixture in a drain overnight. Some sources suggest it can be effective for tough clogs, recommending that you flush the drain with warm water in the morning as part of a monthly cleaning routine. However, other experts advise against leaving the mixture in for extended periods, as its caustic nature could corrode drainpipes if used too often or left in for too long.

There are several common signs that your main sewer line may be clogged. Key indicators include multiple fixtures in your home draining slowly, gurgling sounds coming from drains or toilets, and water backing up into showers, sinks, or toilets. You might also notice water backing up from the plumbing system's drain cleanout, water in your basement drain, or unexplained wet patches on your lawn. Foul odors, such as the smell of raw sewage or rotten eggs, are another common symptom. The most reliable way to confirm a main sewer line clog is to hire a professional plumber to perform a camera inspection.

In most cases, drain cleaners will not clear a clogged sewer line, and they’re likely to damage your plumbing. Sewer lines are several inches wide, meaning any material that clogs it will need to be large. Drain cleaner can work on small clogs, but it usually won’t clear a larger one in a sewer main. Drain cleaners can also easily damage and corrode your plumbing with prolonged contact, and a clog will keep the cleaner in contact with the pipes for an extended period. Hire a professional sewer cleaner instead for a safe fix.

Costs vary by severity and access requirements. Typical pricing ranges from $100 to $350, increasing with complexity or for emergency services.