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Squirrels hate not having access to secure shelter or food sources. Your best line of defense is to make your property less attractive by removing access to these things. There are chemical squirrel repellents, but these have mixed success. According to Pennsylvania State University, you can apply products containing the bittering agent denatonium saccharide to a squirrel's favorite fence, tree, or roof spots. However, you need to reapply repellents regularly, which aren’t scientifically proven effective.

There are quite a few opinions regarding using coffee grinds to keep deer out of your garden, with many people convinced of this method. It makes sense that it could work considering deer have a strong sense of smell and likely do not like the smell of coffee grounds. However, there’s no hard evidence supporting the notion that coffee grounds keep deer away, but it may be worth trying.

Scented mouse deterrents, like peppermint oil, can be effective in the short term. The pungent smells may temporarily repel mice, but they lose effectiveness as the scent fades or mice get used to it. The main drawbacks are frequent reapplication and the fact that these deterrents don't address the root cause of the infestation, such as entry points or food sources. While they can be part of a broader strategy, scented deterrents alone are rarely enough to eliminate a mouse problem.

Possums don’t typically pose a danger to humans—they prefer to stay out of sight. If they feel threatened, they play dead instead of engaging. However, they can become aggressive when cornered, typically when they become trapped inside your home or when a dog chases them. When this happens, it’s best to call a wildlife control service near you to remove possums safely.